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tc s7010  (MedChemExpress)


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    Structured Review

    MedChemExpress tc s7010
    Aurora kinases regulate the expression of α-satellite RNA. ( A ) Representative western blotting demonstrates the inhibition of Aurora kinases in synchronized cells. AURKA inhibitor, <t>TC-S7010</t> (2.5 μM); AURKB inhibitor, AZD1152 (0.25 μM). H3S10P serves as positive control; ACTB, β-actin, serves as the internal loading control. ( B ) Quantification of H3S10P western blot in (A). ( C ) RT-qPCR analysis showing relative α-satellite RNA levels upon Aurora kinase inhibition. DMSO, no drug control. Results are normalized to Async no drug control. The error bars represent SD, n = 6. Statistical significance is calculated using unpaired t-tests and is reported as P < 0.05 *, P < 0.01 **, P < 0.001 ***, P < 0.0001 ****. ( D ) Representative images of α-satellite RNAs (αSAT) smFISH, CREST, and H3S10P IF in cells treated with Aurora kinase inhibitors. Scale bar, 10 μm.
    Tc S7010, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 9 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/tc s7010/product/MedChemExpress
    Average 94 stars, based on 9 article reviews
    tc s7010 - by Bioz Stars, 2026-02
    94/100 stars

    Images

    1) Product Images from "Chromatin-associated α-satellite RNA maintains chromosome stability by reestablishing SAF-A in the mitotic cell cycle"

    Article Title: Chromatin-associated α-satellite RNA maintains chromosome stability by reestablishing SAF-A in the mitotic cell cycle

    Journal: Nucleic Acids Research

    doi: 10.1093/nar/gkaf294

    Aurora kinases regulate the expression of α-satellite RNA. ( A ) Representative western blotting demonstrates the inhibition of Aurora kinases in synchronized cells. AURKA inhibitor, TC-S7010 (2.5 μM); AURKB inhibitor, AZD1152 (0.25 μM). H3S10P serves as positive control; ACTB, β-actin, serves as the internal loading control. ( B ) Quantification of H3S10P western blot in (A). ( C ) RT-qPCR analysis showing relative α-satellite RNA levels upon Aurora kinase inhibition. DMSO, no drug control. Results are normalized to Async no drug control. The error bars represent SD, n = 6. Statistical significance is calculated using unpaired t-tests and is reported as P < 0.05 *, P < 0.01 **, P < 0.001 ***, P < 0.0001 ****. ( D ) Representative images of α-satellite RNAs (αSAT) smFISH, CREST, and H3S10P IF in cells treated with Aurora kinase inhibitors. Scale bar, 10 μm.
    Figure Legend Snippet: Aurora kinases regulate the expression of α-satellite RNA. ( A ) Representative western blotting demonstrates the inhibition of Aurora kinases in synchronized cells. AURKA inhibitor, TC-S7010 (2.5 μM); AURKB inhibitor, AZD1152 (0.25 μM). H3S10P serves as positive control; ACTB, β-actin, serves as the internal loading control. ( B ) Quantification of H3S10P western blot in (A). ( C ) RT-qPCR analysis showing relative α-satellite RNA levels upon Aurora kinase inhibition. DMSO, no drug control. Results are normalized to Async no drug control. The error bars represent SD, n = 6. Statistical significance is calculated using unpaired t-tests and is reported as P < 0.05 *, P < 0.01 **, P < 0.001 ***, P < 0.0001 ****. ( D ) Representative images of α-satellite RNAs (αSAT) smFISH, CREST, and H3S10P IF in cells treated with Aurora kinase inhibitors. Scale bar, 10 μm.

    Techniques Used: Expressing, Western Blot, Inhibition, Positive Control, Control, Quantitative RT-PCR



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    Aurora kinases regulate the expression of α-satellite RNA. ( A ) Representative western blotting demonstrates the inhibition of Aurora kinases in synchronized cells. AURKA inhibitor, <t>TC-S7010</t> (2.5 μM); AURKB inhibitor, AZD1152 (0.25 μM). H3S10P serves as positive control; ACTB, β-actin, serves as the internal loading control. ( B ) Quantification of H3S10P western blot in (A). ( C ) RT-qPCR analysis showing relative α-satellite RNA levels upon Aurora kinase inhibition. DMSO, no drug control. Results are normalized to Async no drug control. The error bars represent SD, n = 6. Statistical significance is calculated using unpaired t-tests and is reported as P < 0.05 *, P < 0.01 **, P < 0.001 ***, P < 0.0001 ****. ( D ) Representative images of α-satellite RNAs (αSAT) smFISH, CREST, and H3S10P IF in cells treated with Aurora kinase inhibitors. Scale bar, 10 μm.
    Tc S7010, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Aurora kinases regulate the expression of α-satellite RNA. ( A ) Representative western blotting demonstrates the inhibition of Aurora kinases in synchronized cells. AURKA inhibitor, <t>TC-S7010</t> (2.5 μM); AURKB inhibitor, AZD1152 (0.25 μM). H3S10P serves as positive control; ACTB, β-actin, serves as the internal loading control. ( B ) Quantification of H3S10P western blot in (A). ( C ) RT-qPCR analysis showing relative α-satellite RNA levels upon Aurora kinase inhibition. DMSO, no drug control. Results are normalized to Async no drug control. The error bars represent SD, n = 6. Statistical significance is calculated using unpaired t-tests and is reported as P < 0.05 *, P < 0.01 **, P < 0.001 ***, P < 0.0001 ****. ( D ) Representative images of α-satellite RNAs (αSAT) smFISH, CREST, and H3S10P IF in cells treated with Aurora kinase inhibitors. Scale bar, 10 μm.
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    chk1 wee1 0 83 tc s 7010 selleckchem  (Selleck Chemicals)
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    Aurora kinases regulate the expression of α-satellite RNA. ( A ) Representative western blotting demonstrates the inhibition of Aurora kinases in synchronized cells. AURKA inhibitor, <t>TC-S7010</t> (2.5 μM); AURKB inhibitor, AZD1152 (0.25 μM). H3S10P serves as positive control; ACTB, β-actin, serves as the internal loading control. ( B ) Quantification of H3S10P western blot in (A). ( C ) RT-qPCR analysis showing relative α-satellite RNA levels upon Aurora kinase inhibition. DMSO, no drug control. Results are normalized to Async no drug control. The error bars represent SD, n = 6. Statistical significance is calculated using unpaired t-tests and is reported as P < 0.05 *, P < 0.01 **, P < 0.001 ***, P < 0.0001 ****. ( D ) Representative images of α-satellite RNAs (αSAT) smFISH, CREST, and H3S10P IF in cells treated with Aurora kinase inhibitors. Scale bar, 10 μm.
    Chk1 Wee1 0 83 Tc S 7010 Selleckchem, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/chk1 wee1 0 83 tc s 7010 selleckchem/product/Selleck Chemicals
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    Image Search Results


    Aurora kinases regulate the expression of α-satellite RNA. ( A ) Representative western blotting demonstrates the inhibition of Aurora kinases in synchronized cells. AURKA inhibitor, TC-S7010 (2.5 μM); AURKB inhibitor, AZD1152 (0.25 μM). H3S10P serves as positive control; ACTB, β-actin, serves as the internal loading control. ( B ) Quantification of H3S10P western blot in (A). ( C ) RT-qPCR analysis showing relative α-satellite RNA levels upon Aurora kinase inhibition. DMSO, no drug control. Results are normalized to Async no drug control. The error bars represent SD, n = 6. Statistical significance is calculated using unpaired t-tests and is reported as P < 0.05 *, P < 0.01 **, P < 0.001 ***, P < 0.0001 ****. ( D ) Representative images of α-satellite RNAs (αSAT) smFISH, CREST, and H3S10P IF in cells treated with Aurora kinase inhibitors. Scale bar, 10 μm.

    Journal: Nucleic Acids Research

    Article Title: Chromatin-associated α-satellite RNA maintains chromosome stability by reestablishing SAF-A in the mitotic cell cycle

    doi: 10.1093/nar/gkaf294

    Figure Lengend Snippet: Aurora kinases regulate the expression of α-satellite RNA. ( A ) Representative western blotting demonstrates the inhibition of Aurora kinases in synchronized cells. AURKA inhibitor, TC-S7010 (2.5 μM); AURKB inhibitor, AZD1152 (0.25 μM). H3S10P serves as positive control; ACTB, β-actin, serves as the internal loading control. ( B ) Quantification of H3S10P western blot in (A). ( C ) RT-qPCR analysis showing relative α-satellite RNA levels upon Aurora kinase inhibition. DMSO, no drug control. Results are normalized to Async no drug control. The error bars represent SD, n = 6. Statistical significance is calculated using unpaired t-tests and is reported as P < 0.05 *, P < 0.01 **, P < 0.001 ***, P < 0.0001 ****. ( D ) Representative images of α-satellite RNAs (αSAT) smFISH, CREST, and H3S10P IF in cells treated with Aurora kinase inhibitors. Scale bar, 10 μm.

    Article Snippet: To inhibit Aurora kinases, 2.5 μM of TC-S7010 (MedChemExpress) and 0.25 μM of AZD1152 (MedChemExpress) were added to the culture medium 0.5 h before sample collection [ , ].

    Techniques: Expressing, Western Blot, Inhibition, Positive Control, Control, Quantitative RT-PCR